Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
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چکیده
منابع مشابه
Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways.
The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of G1 cell cycle progression. Two key substrates of mTORC1 are ribosomal subunit S6 kinase (S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein-1 (4E-BP1). We reported previously that simultaneous knockdown of S6K and eIF4E causes a transforming growth factor-β (TGF-β)-dependent G1 cell cycle arrest in MDA...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2015
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.01.043